Zevalin^(TM):一种放射免疫治疗新药

Zevalin^(TM):A new radioimmunotherapy agent

放射免疫治疗是放射性核素治疗的重要组成和研究的重点之一。ZevalinTM是第一个得到FDA批准的用于治疗复发或顽固性低度恶性非霍奇金氏淋巴瘤的放射免疫治疗制剂。本文综述了该制剂的组成、治疗方案、药理作用机制、辐射剂量和临床试验结果等方面的内容。

Radioimmunotherapy is a major com ponent of radionuclide therapy and always being the main field of re-search.Z evalin TM is the first FDA marketing approved radioimmunotherapy agent which is indic ated for the treatment of relapsed or refractory low grade non-Hodgkin's lymph oma.In this review,the component,therapeutic regimen,pharma-cological mecha nism,radiation dosage and clinical experiment result of Zevalin TM are described respectively.