摘要
目的 :研究金丹肝泰的护肝作用。方法 :用D 氨基半乳糖 (D GalN)制备大鼠急性肝损伤模型。通过检测血清丙氨酸氨基转移酶 (ALT)和天门冬氨酸氨基转移酶 (AST)活性并观察光镜下肝组织的病理学改变 ,探讨中药金丹肝泰对急性肝损伤的保护作用。结果 :口服金丹肝泰浸膏可显著降低急性肝损伤大鼠血清ALT和AST水平 ,减轻肝细胞的变性坏死。结论 :金丹肝泰对肝细胞具有一定的保护作用。
Objective:To testify the protective effect of jindangantai on liver injury. Methods:40 rats were randomly divided into a normal group(10 rats) and acute liver injury models(30 rats) indued by G galactosamine(D GalN). The models were divided into liver injury group, yiganning group, and jingdangantai group(10 rats each). The normal group and liver injury group were given no treatment, while yiganning group were given yiganning pills 6.0 g·kg 1 ·d 1 and jingdangantai group were given jingdangantai 10.0 g·kg 1 ·d 1 , both by perfusation for 7 days. Serum alanine transaminase(ALT) and aspartic transaminase(AST) were detected. Changes of histopathology were observed by light microscopy. Results:The levels of ALT and AST were markedly decreased in Jingdangantai group compared with D GalN group ( P <0.05).The pathological injury was alleviated obviously. Conclusion: jingdangantai has a significant protective effect on liver cells.
出处
《医药导报》
CAS
2002年第11期692-693,共2页
Herald of Medicine
基金
湖北省科技重点发展计划项目 (基金编号 :2 0 0 0 1P170 8)
