含左氧氟沙星方案治疗耐多药肺结核疗效分析

Therapeutic Effect of Levofloxacin on Multidrug Resistant Pulmonary Tuberculosis

目的 :评价左氧氟沙星 (LVFX)对耐多药肺结核 (MDR PTB)的疗效。方法 :12 2例MDR PTB随机分为两组 ,治疗组用LVFX + 3HThEK(C) 6HThE方案治疗 ,对照组用 3HThEPK(C) 6HThEP方案治疗。结果 :疗程结束时治疗组痰菌阴转率和病灶吸收率分别为 88.5 % ,80 .3 % ,明显高于对照组 63 .9% ,5 9.0 % (P <0 .0 5 ) ;治疗组病灶显著吸收率、空洞缩小率和症状好转率均优于对照组。结论 :左氧氟沙星是氟喹诺酮类中治疗耐多药肺结核的有效药物。

Objective:To evaluate the therapeutic effect of levofloxacin (LVFX) on multidrug resistant pulmonary tuberculosis (MDR PTB). Methods:122 cases of MDR PTB were allocated at random to two groups. Chemotherapy regimen: the therapy group were treated with LVFX+3HThEK(C)/6HThE; the control group were treated with 3HThEPK(C)/6HThEP. Results:When chemotherapy was over, the sputum negative conversion rates and focal absorption rates of the therapy group were 88.5% and 80.3%, while the rates of the control group were 63.9% and 59.0% ( P <0.05). The effective focal absorption rates, cavity vanishing rates and symptom improving rates were all higher than those of the control group. Conclusion:Levofloxacin is an effective drug in treating patients with MDR PTB among quinolones.