洛美沙星与环丙沙星治疗急性细菌性感染疗效比较

Effective Comparison of Lomefloxacin and Ciprofloxacin in Treating Acute Bacterial Infection

目的 :比较洛美沙星与环丙沙星治疗急性细菌性感染的临床疗效和安全性。方法 :14 4例患者随机分成两组 ,治疗组 72例 ,用洛美沙星注射液 0 .2～ 0 .4g ,iv ,qd ,疗程 7～ 10d ;对照组 72例 ,用环丙沙星注射液 0 .2～ 0 .4g ,iv ,bid ,疗程 7～ 10d。结果 :总有效率、致病菌清除率治疗组分别为 88.9% ,86.1% ,对照组分别为 84.7% ,80 .6% ,不良反应的发生率治疗组和对照组分别为 5 .6% ,6.9%。结论 :洛美沙星是一个安全、有效的抗菌药物。洛美沙星比环丙沙星给药方便。

Objective:To evaluate the efficacy and safety of lomefloxacin injection and ciprofloxacin in the treatment of acute bacterial infections. Methods:A total of 144 patients were divided into 2 groups. 72 patients of the therapy group received lomefloxacin injection 0.2-0.4 g, iv grip, qd, for 7-10 d. 72 patients of the control group received ciprofloxacin injection 0.2- 0.4 g, iv grip, bid, for 7-10 d. Results:The effective rate and the bacterial clearing rate of the therapy group were 88.9% and 86.1 % respectively, and those of the control group were 84.7% and 80.6% respectively. The adverse reaction of the therapy group was 5.6% , and that of the control group was 6.9%. Conclusion: Lomefloxacin is an effective and safe antibacterial drug in the treatment of bacterial infections. The usage of lomefloxacin injection is convenienter than ciprofloxacin's.