期刊文献+

咪达普利降压疗效及对左心室功能影响的观察 被引量:2

下载PDF
导出
摘要 目的 :探讨咪达普利治疗原发性高血压的降压疗效及对左心室功能的影响。方法 :每日早餐后 1次口服咪达普利 10mg ,疗程 3个月。治疗前后均行彩色多普勒超声检测心功能及 2 4h动态血压监测。结果 :用药后患者日间血压均值、夜间血压均值明显下降 (P <0 .0 5 ) ,E峰血流速度明显增高 (P <0 .0 1) ,A峰血流速度明显下降 (P <0 .0 5 ) ,E A比值明显增高 (P <0 .0 5 ) ,射血分数、心排血量无明显变化。结论 :咪达普利对原发性高血压患者长期治疗可有效降低血压 ,改善左心室舒张功能。
出处 《医药导报》 CAS 2002年第11期726-726,共1页 Herald of Medicine
  • 相关文献

参考文献1

共引文献6

同被引文献31

  • 1王丽萍,杨方.基质金属蛋白酶及其抑制因子与心肌纤维化[J].中国动脉硬化杂志,2005,13(4):517-519. 被引量:16
  • 2刘雪平,祝玮玮,刘静静,迟翔宇,邵建华.贝那普利和氯沙坦联合阻断肾素—血管紧张素系统对自发性高血压大鼠左心室重构的影响[J].中国动脉硬化杂志,2006,14(1):4-8. 被引量:7
  • 3Hirota Y,Kawamura K,Ooyasi A,et al.Phase I study of TA-6366(I)-single oral administration[J].J Clin Ther Med,1992,8:507-522.
  • 4Murata T,Matsumoto Y,Kashida T,et al.Difference among angiotensin-converting enzyme inhibitors in potentiating effects on bradykinin-induced microvascular leakage in guinea pig airways[J].Jpn J Pharmacol,1995,69:111-118.
  • 5Zweiker R,Stoschitzky K,Maier R,et al.Efficacy and safety of the ACE-inhibitor imidapril in patients with essential hypertension[J].Acta Med Austriaca,2002,29:72-76.
  • 6Wang JM,Wang Y,Zhu ZS,et al.Diverse effects of long-term treatment with imidapril and irbesartan on cell growth signal,apoptosis and collagen type I expression in the left ventricle of spontaneously hypertensive rats[J].Life Sci,2004,75(4):407-420.
  • 7Kim NN,Villegas S,Summerour SR,et al.Regulation of cardiac fibroblast extracellular matrix production by bradykinin and nitric oxide[J].J Mol Cell Cardiol,1999,31(2):457-466.
  • 8van Veldhuisen DJ,Genth-Zotz S,Brouwer J,et al.High-versus low-dose ACE inhibition in chronic heart failure:A double-blind,placebo-controlled study of imidapril[J].J Am Coll Cardiol,1998,32:1811-1818.
  • 9Katayama S,Kikkawa R,Isogai S,et al.Effect of captopril or imidapril on the progression of diabetic nephropathy in japanese with type I diabetes mellitus:a randomized controlled study[J].Diab Res and Clin Prac,2002,55:113-121.
  • 10Sakamoto T,Barnes PJ,Chung KF.Effects of CP96,345,a non-peptide NK1 receptor antagonist,against substance P-,bradykinin-and allergen-induced airway microvascular lcakage and bronchoconstriction in the guinea pig[J].Eur J Pharmacol,1993,231:31-38.

引证文献2

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部