病毒感染对慢性阻塞性肺病患者免疫功能的影响

Influence of viral infection on immune function of patients with chronic obstructive pulmonary disease

为探讨病毒感染对慢性阻塞性肺病 (COPD)患者免疫功能的影响 ,检测了 6 4例 COPD急性发作期患者的呼吸道病毒特异抗体 Ig G、Ig M,自然杀伤细胞活性 (NK- A) ,T淋巴细胞亚群及体液免疫 Ig A、Ig G、Ig M。结果显示 ,COPD急性发作期呼吸道合胞病毒 (RSV)、腺病毒 (ADV)、柯萨奇病毒 (COX)、巨细胞病毒 (CMV)特异抗体 Ig G、Ig M的阳性率分别是 4 5 %、2 5 % ,2 2 %、2 8%及 11%、5 %和 3%、5 %。病毒抗体阳性组 NK- A和 T淋巴细胞亚群显著低于病毒抗体阴性组 ,而体液免疫无显著差异。提示病毒感染对 COPD患者的细胞免疫有明显抑制作用 ,可能是

To investigate the influence of viral infections on the immune function of patients with chronic obstructive pulmonary disease(COPD) during acute exacerbations.Examined were the specific antibody (IgG,IgM) of respiratory virus,the natural killer cell activity (NK A)and T lymphocyte subsets from 64 patients with COPD.Results showed that the ratio of specific antibody(IgG,IgM)of respiratory syncytialvirus(RSV),adenovius(ADV),coxsacki evrus(COX),Cytomegalovirus(CMV) were 45%,25%,22%,28%and 11%,5%,3%,5% respectively.The natural killer cell activity(NK A),T lymphocytes subsets were significantly lower in viral antibody positive groups than in viral antibody negative groups.It is suggested that the viral infections depress the cellular immunity and be a factor of frequent acute exacerbations of COPD.