白介素-2、α-干扰素对人皮肤瘢痕组织成纤维细胞增殖的影响

The influence of interleukin-Ⅱand IFN-αon proliferation of fibroblasts from keloids and nomal skin

目的观察白介素-2、α-干扰素对人皮肤瘢痕组织成纤维细胞增殖的影响。方法通过细胞培养的方法研究了瘢痕疙瘩和正常皮肤的成纤维细胞对白介素-2(200u/ml)和α-干扰素(100u/ml)的反应。结果白介素-2和α-干扰素抑制瘢痕疙瘩及正常皮肤成纤维细胞的生长。结论白介素-2和α-干扰素是瘢痕形成过程中的一种负性调节因子,有望在病理性瘢痕防治中发挥重要作用。

Objecbive To explore the influence of on proliferation of interlenkin-Ⅱand IFN-αfibroblasts from Keloids and normal skin.Methods The means of cell culture was used to i nvestigate the response of fibrobla sts from keloids and normal skin to nt erleukin-Ⅱ(200u /ml )and IFN-α(100u /ml ).Results nterleukin-Ⅱand IFN-αcould inhibit the growth of fibrobla sts from keloids and normal skin.Con-clusion Interleukin-Ⅱand IFN-αare cytokine with downregulation effect on scar formation,and suggest t hat Interleukin-Ⅱand IFN-αcan play an important role in the prevent ion and treatment of scars.