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Experiment research on promoting survival rate of tension skin flap after meshed relaxing short incision suture

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摘要 Objective To observe effects of meshed relaxing short incisions on the level of superoxide dismutase and malondialdehyde in rat tension skin flap, and to investigate the mechanism of meshed relaxing short incisions (MRSI) on wound healing process of tension skin flap. Method An experimental model was designed to investingate he changes of superoxide dismutase (SOD) and malondialdehyde (MDA) in rat shin flap tissue each period of wound healing (12h,24h,48h,72h after suture). In the meantime, the biochemical reaction were employed. Results Our results showed that SOD content in rat skin flap tissue from MRSI group were significant higher than that of hypertension group (P≤0.05), while MDA content was significantly lower (P≤0.05). Conclusion The decrease of MDA contents may be one of the causes that MRSI improves microcirculation of skin flap, and reduces edema and facilitates healing of skin flap.
机构地区 ChanghaiHospital
出处 《中国临床康复》 CSCD 2002年第20期3122-3133,共12页 Chinese Journal of Clinical Rehabilitation
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