临床药师参与治疗2例多重耐药肺炎链球菌脑膜炎患儿实践体会

Pharmaceutical Practice for Two Children with Multi-Drug Resistant Streptococcus Pneumoniae Meningitis by Clinical Pharmacists

目的:探讨临床药师在多重耐药肺炎链球菌脑膜炎患儿抗感染治疗中的作用。方法:临床药师参与2例多重耐药肺炎链球菌脑膜炎患儿的治疗过程。2例患儿根据药敏结果选择万古霉素作为主要抗感染药物,感染指标未下降,病情恶化。临床药师分析了万古霉素治疗效果不佳的原因,建议医师换用利奈唑胺,并对利奈唑胺在儿童细菌性脑膜炎中的应用进行了分析。结果:2例患儿在使用利奈唑胺治疗2周后,感染得到控制,好转出院。结论:临床药师参与抗感染方案制定,可以为医师提供参考,最终使患者获益。

Objective:To explore the role of clinical pharmacists in the anti-infection treatment for children with multi-drug resistant Streptococcus pneumoniae meningitis.Methods:Clinical pharmacists participated into the treatment process of two children with multidrug resistant S.pneumoniae meningitis.Vancomycin was selected as the main anti-infection drug according to the drug sensitivity results.The infection index did not decrease and the condition deteriorated.The clinical pharmacists analyzed the reasons for the poor efficacy of vancomycin treatment,suggested the clinicians to use linezolid,and analyzed the application of linezolid in multi-drug resistant S.pneumoniae meningitis in children.Results:After two weeks of treatment with inezolid,the infection was controlled and the patients were discharged from the hospital.Conclusion:The involvement of clinical pharmacists in the formulation of anti-infection programs can provide reference for clinicians and ultimately benefit the patients.