脑膜瘤P^(53)、P^(63)的表达及与术后复发的关系

The relationship between the expression of P^(53),P^(63) and the recurrence of meningiomas after tumor total removal

应用免疫组化方法检测 70例脑膜瘤 P53、P6 3表达情况 ,分析其与脑膜瘤组织学分级、复发的关系。结果 :32例复发性脑膜瘤 P53表达阳性 7例 (2 1.9% ) ,P6 3表达阳性 14例 (4 3.6 % ) ;38例初发性脑膜瘤中 P53表达阳性 5例 (13.2 % ) ,P6 3表达阳性 18例 (4 7.4 % )。随组织学分级的升高 ,P53表达阳性者明显增多 (P<0 .0 5 ) ;P6 3表达阳性与组织学分级无明显相关性 (P>0 .0 5 )。 38例初发性脑膜瘤中 P6 3阳性率 (18/ 38)与复发性脑膜瘤中阳性阳性率 (14 / 32 )无显著性差异 (P>0 .0 5 )。认为 P53表达水平与组织学分级有关 ,与肿瘤复发无显著性相关 ;P6 3表达水平对脑膜瘤的组织学分级和预测复发均无显著性意义。

To detect the expression of P 53 , P 63 and study their significance in predicting the recurrence of meningiomas after tumor total removal and in relation to the histological features,specimens of 70 patients with meningioma were detected for the expression of P 53 , P 63 with immunohistochemistry method The histological grade, tumor recurrence, the positive expression of P 53 , P 63 and the interaction between them were statistically analyzed The results showed in the 32 cases with recurrent meningiomas, 7 cases were positive (21 9%) of P 53 , 14 (43 6%) cases were positive of P 63 In the 38 cases with primary meningiomas, 5 (13 2%) cases were positive of P 53 , 18 (47 4%) cases were positive of P 63 No significant difference was found between the expression of P 53 and recurrence (P<0 05), but the expression rates of them in the anaplastic group were higher than those in the benign group (P<0 05) We concluded that no relationship between the expression of P 53 , P 63 and recurrence