小肠脂肪酸结合蛋白基因多态性与2型糖尿病相关性的研究

A study on the relationship between poiymorphism of intestinal fatty acid binding protein gene and type 2 diabetes mellitus

应用聚合酶链反应 (PCR)技术结合短串联重复序列 (STR)的方法检测了 10 1例 2型糖尿病患者及10 2例正常对照者的小肠脂肪酸结合蛋白 (FABP2 )基因型。结果显示两组研究对象的 2、3、4、5等位基因的分布频率分别为 0 .0 4、0 .6 3、0 .32、0 .0 1和 0 .0 6、0 .6 3、0 .2 8、0 .0 3,两组比较无差异 (P>0 .0 5 )。说明基因多态性与 2型糖尿病发病无相关性 ,不是其主要致病基因。

Polymorphism of intestinal fatty acid binding protein(FABP2)gene was determined by polymerase chain reaction(PCR)and short tandem repeat(STR)in 101 type 2 diabetic patients and 102 normal controls The results showed that the frequencies of FABP 2 allel 2,3,4 and 5 were 0 04,0 63,0 32,0 01 in patients with type 2 diabetic patients and 0 06,0 63,0 28,0 03 in normal population respectively(P>0 05) FABP 2 gene does not play a significant role in type 2 diabetes mellitus in Chinese