摘要
脊椎动物Sox基因是一类高度保守的基因家族 ,它们编码一类转录因子 ,参与多种发育过程的调控。这个家族的共有特征是Sox蛋白具有一个约 79个氨基酸 ,可与DNA特异结合的HMG盒区。该基因家族成员众多复杂 ,对它们的基因结构、功能及进化关系的研究有助于对该基因家族的全面认识。利用已克隆的全部脊椎动物全长核苷酸 /蛋白质数据 ,对这些数据进行序列比对及进化树的构建 ,分析Sox基因家族成员的分类及分子进化模式。
Sox genes of vertebrate are highly evolutionarily conserved, which encode different transcriptional factors involved in various developmental processes. Sox family is characterized by a sequence specific DNA binding HMG box containing about 79 amino acids. To realize the complexity of genes of the Sox family in the structures, functions and their evolutionary relationships, in the present study by utilizing all available complete nucleotide/protein sequence data of vertebrate Sox genes, we performed multi sequence comparison and construction of phylogenic tree, and the grouping of Sox family members and the pattern of their molecular evolution was also analyzed.
基金
国家自然科学基金资助 (批准号 :3 0 14 0 0 13 )~~
