摘要
为探讨体力运动对慢性应激引起的海马损伤的影响 ,在大鼠整体水平检测海马长时程增强 (long termpotentiation ,LTP)和血浆糖皮质激素 (glucocorticoids ,GCs)水平。结果发现 ,8周的跑轮运动 (wheelrunning)会明显减缓随后 2 1d的慢性束缚应激对海马齿状回 (dentategyrus ,DG)LTP的抑制 ,且可维持血浆GCs水平正常。结果提示 ,长期体力运动对海马有保护作用 ,可减缓慢性应激引起的损伤。
The long term potentiation (LTP) in the hippocampal dentate gyrus and the plasma glucocorticoids level were observed in rats to study the effects of physical exercise on chronic stress induced hippocampal damages. Eight week spontaneous wheel running exercise could attenuate the suppression of LTP induced by 21 day restraint stress, and maintain the normal plasma glucocorticoids levels. It is suggested that long term physical exercise may protect the hippocampus from stress induced damages.
出处
《生理学报》
CAS
CSCD
北大核心
2002年第5期427-430,共4页
Acta Physiologica Sinica
