利福贲丁联合治疗肺结核40例临床观察

Forty Cases Clinical Observation on Rifapentine Remedy to Tuberculosis

目的 观察利福贲丁治疗肺结核的效果和不良反应。 方法 选择 80例肺结核患者 ,随机分为利福贲丁组和利福平组 ,两组各选初治病例 30例 ,复治病例 10例 ,其中每组初治涂阳病例各 15例 ,复治涂阳 5例。利福贲丁组采用 2 HLEZ/( 4- 6 ) HL E方案治疗 ,利福平组采用 2 HREZ/( 4- 6 ) HRE方案治疗 ,其中 ,H为异烟肼 ,Z为砒嗪酰胺 ,E为乙胺丁醇 ,R为利福平 ,L为利福贲丁。 结果 两组痰菌阴转率、X线病灶吸收率基本相似 ,均为 10 0 % ;利福贲丁组的治愈加好转率优于利福平组 ;利福贲丁组的肝功能转氨酶损害明显少于利福平组 ( P <0 .0 1)。 结论 利福贲丁治疗肺结核的疗效高 ,毒副作用小 。

Objective The aim of this study was t observe the effect and side effect of Rifapentine remedy to Tuberculosis Methods The method was that chose 80 tuberculosis cases and randomly divided them into experimental group(applied Refapentine) and control group(applied Rifampin) Each group included 30 first visit cases(including 15 positive cases in smear examination) and 10 return visit cases( including 5 positive cases in smear examination) The experimental group were treated with αHLEZ/(4-6)HLE remedy, and the control group with LHREZ/(4-6)HRE remedy H Z E R and L respectively represent Isoniazid, Pyrazinamide, Ethambutol,Rifampin and Rifapendine Results The tesults showed that both groups got similarities as 100% in rate on phlegm bacterias turming megative and focus absorption in X- ray appearance Compared with the control group, the experimental group got a higher performance in cure rate plus improvement rate and lower liver function transaminase damage(P<0 01) Conclusion Rifaspetine is the ideal remedy for tuberculosis because of its high curative effect and low toxic and side effect