精神疾病患者血清一氧化氮含量的研究

A study of the serum nitric oxide content in psychotic patients

目的 探讨一氧化氮(Nitric Oxide,NO)在精神病患者血清中的含量及其临床意义。方法 采用化学比色法检测了356例精神疾病患者血清中NO含量。结果 精神疾病患者血清中NO含量高于对照组(P<0.01);发病年龄在“51岁～”组NO含量最低,病程在“15年～”组NO含量最高;精神分裂症家族史阳性者血清中NO高于精神分裂症阴性家族史者(P<0.05)。结论 精神疾病患者血清中NO含量增高可能是精神症状产生的原因之一。

Objective To explore the serum content of nitric oxide (NO) in the psychotic patients and its clinical significance . Method The serum contents of NO in 356 psychotic patients were measured with chemical colorimetry. Results The serum ON contents were higher in psychotic patients than that in controls ( P < 0.01) . The NO content of patients whose onset ages were over fifty was the lowest while those of the patients with the couse of disease over fifteen was the highest. The schizophrenics with family history had higher serum NO contents than those without family history ( P < 0.05). Conclusion NO increasing accelerates the production of free radic in their bodies, which leads to cortical fun-tion disorder and hence disturbs the mental state .