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钾离子通道与癫痫 被引量：1

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摘要 K+通道在调节神经元的兴奋性方面有十分重要的作用。K+通道与癫痫痈关系的研究日益受到重视。本文着重阐述了K+通道的分类及特性、分子结构、K+通道与癫痫的关系、K+通道基因突变与癫痫方面的研究进展。
作者 关文标 佴玉
机构地区 兰州医学院附属白银医院
出处 《国外医学（神经病学．神经外科学分册）》 2002年第5期442-444,共3页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）
关键词 钾离子通道 癫痫 分子结构 基因突变
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献19

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同被引文献20

  • 1Kanemoto K,Kawasaki J,Miyamoto T,etal.Interleukin (IL) 1 beta,IL-1 alpha,and IL-1 receptor antagonist gene polymorphisms inpatients with temporal lobe epilepsy.Ann Neurol,2000,47:571-574.
  • 2Ben-Ari Y.Cell death and synaptic reorganizations produced byseizures.Epilepsia,2001,42 Suppl 3:S5-S7.
  • 3Bordey A,Sontheimer H.Properties of human glial cells associated with epileptic seizurefoci.Epilepsy Res,1998,32:286-303.
  • 4Steinhauser C,Seifert G.Glial membrane channels and receptors in epilepsy:impact for generation and spread of seizure activity.Eur J Pharmacol,2002,447:227-237.
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  • 6Wickman K,Pu WT,Clapham DE.Structural characterization of the mouse Girkgenes.Gene,2002,284:241-250.
  • 7Roll P,Szepetowski P.Epilepsy and ionic channels.Epileptic Disord,2002,3:165-172.
  • 8Karschin C,Dissmann E,Stühmer W,et al.IRK(1-3) and GIRK(1-4) inwardly rectifying K^+ channel mRNAs are differentially expressed in the adult rat brain.J Neurosci,1996,16:3559-3570.
  • 9Neusch C,Weishaupt JH,Bahr M.Kir channels in the CNS:emerging new roles and implications for neurological diseases.Cell Tissue Res,2003,311:131-138.
  • 10Lux HD,Heinemann U,Dietzel I.Ionic changes and alterations in the size of the extracellular space during epileptic activity.Adv Neurol,1986,44:619-639.

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国外医学（神经病学．神经外科学分册）
2002年 第5期

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