成人急性病毒性脑炎临床分析及抗病毒药物的疗效

Clinial Andlysis of Acute Viral Encephalitb in Adali and Cnrative Effect of Antivival Drugs

目的 探讨成人急性病毒性脑炎的临床特点,比较几种抗病毒药物的疗效。方法 回顾性分析并总结62例急性病毒性脑炎的病因学、临床神经病学、神经影像学资料,比较病毒唑、阿糖胞苷及无环鸟甙三种抗病毒药物疗效。结果 在发病早期血清单纯疱疹病毒性抗原阳性率为38.10％,脑脊液为35.71％,血清巨细胞病毒抗原阳性率为21.43％,脑脊液为16.67％。无环鸟苷总有效率明显高于、死亡率明显低于病毒唑和阿糖胞苷。结论 成人急性病毒性脑炎中以单纯疱疹和巨细胞病毒感染为主,无环鸟苷是一种特效、低毒抗疱疹病毒药。

To probe the clinical features of acute viral encephalitis in adult,compere the curative effecfs of several antiviral drugs. Methods Canses of disease, clinical features and image dafa of nerve were analysed retrospectively. The Curative effects of virazole, Are - c and aciclovir were compared. Results During early period of the disease, the positive rate of serm herpes simplex vir黶 antigen was 38.10% ,and it wds 35. 71% , in cerebrospinal fluid.the positive rate of serm cytomegalovirus antigen was 21.43% ,ant it was 16.67% in cytomegalovirus. The total effetive rate of aciclovir was higher than those of virazole and Ara- c,but the death rate is lower. Conclnsions The main cause of acute viral encephalitis in adult is herpes simplex vir黶 and cytomegalovirus. Aciclovir is a kind of specific antiviral drug with lower toxicity.