绝经后妇女缺血性脑卒中患者性激素变化及其意义

Study on Sex Hormone Changing in Postmenopansal Women with Ischemic Stroke

目的 探讨绝经后妇女缺血性脑卒中患者性激素变化规律及其与血脂的关系。方法 测定45例绝经2年以上发病3天内急性动脉硬化性脑梗死患者,35例绝经2年以上健康妇女和35例绝经前行经期健康妇女的血清雌二醇(E_2)、孕酮(P)、促卵泡刺激素(FSH)、促黄体生成素(LH)及血脂谱。结果 脑卒中患者E_2水平,较绝经前妇女下降57％,而绝经后健康妇女下降51％。相关分析表明,E_2与TC、LDL-C呈负相关,与HDL-C、HDL-C_2呈正相关,相关系数分别为- 0.6178、-0.5326、0.4371和0.5649,(P均<0.01)。结论 绝经后动脉硬化性缺血性脑卒中与性激素失调有关,影响绝经后妇女血脂水平的可能是雌二醇对动脉硬化性脑卒中发挥作用。

To investigate the sex hormone changing and the relationship with blood lipid level in postmenopausal women with ischemic stroke. Methods 45 postmenopausal women with acute arterosclerosis cerebral infarction within 3 days( mean age 62. 5 ± 2.4 years) , 35 postmenopausal health women (age 61.7 ± 3. l years) and 35 premenopausal health women (age 39.4 ± 3.8 years) as control were selected to compare the serum levels of estradiol(E2)progesterone(P),follicle stimulating hormone(FSH) Uuteinizing hormon(LH) and blood lipid. Results E2 level showed a 57% decrease in the stroke women and a 51 % de-crease in the postmenopausal health women compared with the premenopausal ones. Correlation analysis showed that serum E2 level was negatively correlated to serum levels of TC(r= -0.617 8, P < 0.01) and LDL-C(r= -0.5326, P < 0.01), but positively associated with HDL - C(0. 437 1, P < 0.01) and HDL2 - C( 0.564 9, P < 0.01). Conclusions Acute arterosclerosis ischemic stroke of postmenopausal wom-en is related to the endogenous sex hormones disordor, and the effect of E3 to the lipid may be one of the mech-anisms of arterosclerosis ischemic stroke in postmenopausal women.