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延边地区朝鲜族儿童维生素D受体基因Fok I位点多态性研究 被引量:4

Polymorphism of vitamin D receptor gene Fok I in the Korean children in Yanbian district
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摘要 目的了解延边地区朝鲜族儿童维生素D受体(vitamin D receptor,VDR)基因Fok I位点的多态性分布特点,为进一步研究VDR基因多态性与骨代谢疾病的关系打下基础。方法应用荧光定量PCR方法,检测98名延边地区朝鲜族儿童的VDR基因Fok I位点多态性,分析该基因型和等位基因频率分布,并与已报道的其他民族、种族的数据进行比较。结果本研究人群VDR基因ff、Ff、FF基因型的分布频率分别为23%、40%、37%,该分布情况与国内云南阿昌族、甘肃东乡族以及国外美国黑人、尼日利亚人的差异具有统计学意义(P<0.05)。结论延边地区朝鲜族儿童VDR基因Fok I位点基因型和等位基因的频率分布特征有其自身的特点。 Objective To explore the polymorphism distribution of vitamin D receptor(VDR)gene FokⅠ in the Korean children in Yanbian Province for further study on relation between VDR gene polymorphisms and metabolic bone disease.Methods A total of 98 Korean children were recruited and collected oral epithelial cells.Genome DNA for fluorescence quantitative PCR to detect SNP of FokⅠ were extracted.The results were compared with the distribution frequency of FokⅠ in other nations or races. Result The frequency of Fok Ⅰ(ff,Ff,FF)in Korean children were 23%,40%,37% respectively,which were significant difference to Achangs,Dongxiang nationality,Americans and Nigerian(P<0.05). Conclusion Fok Ⅰ polymorphism distribution in Korean children exhibits its own characteristics.
出处 《中国儿童保健杂志》 CAS 2015年第4期351-353,共3页 Chinese Journal of Child Health Care
关键词 维生素D受体 基因多态性 朝鲜族 vitamin D receptor polymorphism Korean
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