早产儿高胆红素血症的诊疗进展

Progress in diagnosis and treatment of hyperbilirubinemia in premature infants

早产儿出生时胎儿红细胞数比例高,早期大量胎儿红细胞破坏,胆红素来源增加,肝脏功能不成熟,其摄取、结合、排泄胆红素功能差,易出现高胆红素血症。对于胎龄≥35周的新生儿,已有相应的光疗曲线及小时胆红素列线图作为诊断或干预标准,而胎龄<35周的早产儿尚缺乏公认的干预指南。本文就早产儿高胆红素血症的最新诊断和治疗进展进行综述。

Preterm born with a high proportion of fetal red blood cells would have,a large number of early fetal red blood cell damaged,and increased bilirubin source.Moreover preterms liver function is immature.And its poor intake,utitization and excretion of bilirubin dysfunction,makes preterms prone to hyperbilirubinemia.For neonates with gestational age over 35 weeks,the corresponding phototherapy curve and the hourly bilirubin line chart have been used as diagnostic or intervention criteria.However preterm infants with gestational age less than 35 weeks still lack an accepted intervention guideline.This article reviews the latest diagnosis and treatment of hyperbilirubinemia in premature infants.