2～3岁孤独症谱系障碍儿童与正常儿童叫名反应的比较

Comparison of response to name between autism spectrum disorder children and healty children aged 2～3 years old

目的探讨2~3岁孤独症谱系障碍(ASD)儿童和正常儿童间叫名反应的客观量化的指标差异。方法纳入2016年5-8月在中山大学附属第三医院儿童发育行为中心确诊的2~3岁ASD儿童22名,正常儿童21名。在多模态实验室中进行标准流程叫名反应,通过评估师打分和计算机自动分析系统分析在正常情景反应下两组儿童的叫名反应的特征和差异。结果 1)ASD组与正常组儿童的叫名反应评分比较,差异有统计学意义(Z=15.764,P<0.01)。2)对比计算机自动分析叫名反应的反应时间和持续时间,ASD和正常组在反应时间上的差异无统计学意义(Z=-1.593,P=0.113),ASD的持续时间短于正常组儿童,差异有统计学意义(Z=-3.4,P=0.001)。结论 2~3岁ASD儿童的叫名反应差于正常儿童,ASD儿童早期叫名反应的异常症状表现为目光对视更少和持续时间更短。

Objective To explore the objectivity differences of responses to name between autism spectrum disorder(ASD)and children with normal development.Method A total of 22 ASD children diagnosed in Children Development &Behavioral Center of the Third Affiliated Hospital of SUN Yat-sen University from May to August in 2016 and 21 controls was enrolled in this study.In standard procedure testing the response to name.After that,two professional evaluators scored the response to name,and automatic system computational analyzed the time of response to name and duration to response.Result 1) There were no significant differences in scores of response to name between ASD children and normal children (Z=15.764,P<0.01).2) The computational analysis showed that in response to name procedure,the response time showed no differences in ASD group and control group (Z=-1.593,P=0.113),But response duration was shorter in ASD group than that in control group (Z=-3.4,P=0.001).Conclusions Compared to normal children,2~3-year-old children with ASD have inferior behavior in response to name.The characteristics of abnormal response to name in ASD children include less eye contact and shorter response duration.