南昌市行为问题儿童血清双酚A、性激素水平调查

Investigation of serum bisphenol-A and sex hormones in children with behavior problem from Nanchang

目的了解南昌市学龄儿童行为问题发生情况及与双酚A(BPA)、性激素的相关性。方法调查南昌市4所小学的176名7~11岁儿童,由家长统一填写调查问卷表及Conners父母问卷调查表。采用ELISA法测定血清BPA含量,采用直接化学发光法测定血清中黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、睾酮(T)含量。结果 176名调查儿童行为问题检出率为19.3%,其中心身问题检出率最高(6.8%);男童学习问题和多动指数检出率高于女童;8岁儿童行为问题检出率最高;血清BPA水平是儿童焦虑的独立预测因素(β=0.172);母亲文化程度高中及以上和高性激素水平(E2和T)是儿童行为问题的独立保护因素(OR母亲文化=0.649;OR性激素=0.801)。结论南昌市学龄儿童行为问题发生率较高,提高母亲文化程度、减少BPA暴露和控制性激素水平降低有助于减少儿童行为问题的发生。

Objective To investigate the prevalence and characteristics of children's behavior problems,and to study the influencing factors about children's behavior problems.Methods A total of 176 children aged from 7 to 11 were chosen from four primary schools in Nanchang,and their parents were asked to fill in the questionnaire and Conners Parent Symptom Questionnaire(PSQ).The concentrations of BPA in serum samples were measured by using ELISA,and the sex hormones levels of luteinizing hormone(LH),follicle stimulating hormone(FSH),estradiol(E2),testosterone(T)were detected by chemiluminoimmunoassay.Results The proprotion of children's behavior problems was 19.3%,among which psychosomastic disorder was the highest(6.8%).The prevalence of learning problem and hyperactivity impulse index in boys were higher significantly than that of girls prominently.The detection rate on behavior problems of children aged 8 years was the highest.The levels of serum BPA positively affected children's anxiety(β=0.172).After adjustment for potential confounders,potential protective factors might be high level of mother's education and E2 or T [OR mother's education=0.631;OR(E2 and T)=0.804].Conclusions The detection rate of behavior problems among children in Nanchang is high.Measures like improving mother's education,reducing BPA exposure,and controlling the level of sex hormones decrease need to be taken to prevent child behavior problems.