妊娠期糖尿病对子代肺成熟度影响的代谢组学研究进展

Metabolomics progress on the influence of gestational diabetes mellitus on children′s lung maturity

妊娠糖尿病如果孕妇继续保持高血糖并且控制不理想,会刺激胎儿胰岛素分泌增多,引起孕妇高胰岛素血症。当母亲的胰岛素浓度升高时,会抑制胎儿糖皮质激素的分泌,最终导致胎儿肺泡发育滞后及低血糖症。目前,胎肺成熟度是通过羊水泡沫测试来判断的,行羊膜腔穿刺术属有创操作存在一定弊端,现今临床上存在较大的争议。随着代谢组学在妊娠期糖尿病中的研究越来越多,本文主要就代谢组学在妊娠期糖尿病对子代肺成熟的影响的研究进展进行阐述。

If pregnant women with gestational diabetes mellitus(GDM)maintain hyperglycaemia with bad control,fetal insulin secretion will be stimulated to grow in quantity,thereby causing maternal high insulin hematic disease.When maternal insulin concentration increases,the fetus glucocorticoid secretion will be suppressed,which will finally lead to fetal alveolus development lag and hypoglycemia.At present,fetal lung maturity is judged by amniotic fluid bubble test,and there is a big controversy about line amniotic cavity puncture because it is an invasive operation and has certain disadvantages.With the increasing researches on metabonomics of gestational diabetes,this review will summarize recent progress on the impact of child lung mature from the perspective of metabolomics.