围生期解脲脲原体感染的研究进展

Research progress on perinatal ureaplasma urealyticum infection

解脲脲原体(UU)是一种条件致病微生物,感染传播途径包括性接触传播、母婴传播和医源性传播。成人UU感染可导致非淋菌性尿道炎以及不孕不育,引发各种不良妊娠结局。新生儿UU感染可引起慢性肺炎、支气管肺发育不良、脑室内出血、新生儿脑膜炎、坏死性小肠结肠炎以及早产儿视网膜病变等。UU感染治疗首选大环内酯类抗生素。预防UU感染的关键是加强对育龄期妇女的筛查,早发现早诊断早治疗。

Ureaplasma urealyticum(UU)is a conditionally pathogenic microorganism,which transmits primarily through sexual contact,mother-to-child transmission and iatrogenic transmission.UU infection in adults can lead to nongonococcal urethritis and infertility,and is associated with adverse pregnancy outcomes.Neonatal UU infection can cause chronic pneumonia,bronchopulmonary dysplasia,intraventricular hemorrhage,neonatal meningitis,necrotizing enterocolitis,neonatal retinopathy and so on.Macrolide antibiotics is preferred for UU treatment.The key to preventing UU infection is to strengthen routine UU infection screening in child-bearing women for the purpose of early detection,early diagnosis and early treatment.