儿童维生素D缺乏对血清铁蛋白的影响

Effect of vitamin D deficiency on serum ferritin in children

目的了解东莞市儿童维生素D(VD)缺乏现状,研究VD缺乏对血清铁蛋白的影响。方法选取2016年11月-2018年4月间在东莞市儿童医院体检的6个月~14岁儿童,检测血清铁蛋白及VD浓度,采用SPSS24.0进行统计分析。结果 VD降低的比例为34.73%,而婴幼儿组、学龄前组和学龄组的VD降低的比例分别为19.75%、65.45%和77.78%,储存铁减少的比例为22.42%。VD正常组血清铁蛋白浓度高于VD不足组及VD缺乏组(F=6.21,P=0.002)。年龄增大(OR=0.312,95%CI:0.233~0.419,P<0.001)为储存铁减少的保护因素,VD不足(OR=1.377,95%CI:1.109~1.710,P=0.004)为储存铁减少的危险因素。结论本院健康体检儿童VD缺乏的比例较高,且随着年龄增大而升高,VD缺乏为血清铁蛋白降低的危险因素之一。临床工作中有必要延长VD制剂补充的年限,同时,在铁缺乏或者补充铁剂疗效欠佳的病例,建议同时检测VD浓度。

Objective To understand the status quo of vitamin D deficiency in children,and to analyze the effects of vitamin D deficiency on serum ferritin.Methods Children aged 6 months to 14 years,who took physical examination in Dongguan Children′s Hospital from November 2016 to April 2018 were enrolled in this study.Serum ferritin and vitamin D concentrations of children were measured.Statistical analysis was performed by SPSS 24.0.Results The overall prevalence rate of vitamin D deficiency was 34.73%,and the prevalence rate of vitamin D deficiency in infants,preschoolers and school-age children was 19.75%,65.45%and 77.78%,respectively.The rate of iron depletion was 22.42%.The serum ferritin level in vitamin D normal group was higher than that in vitamin D depletion group and vitamin D deficiency group(F=6.21,P=0.002).Older age was a protective factor for iron depletion(OR=0.312,95%CI:0.233-0.419,P<0.001),and vitamin D deficiency was a risk factor for iron depletion(OR=1.377,95%CI:1.109-1.710,P=0.004).Conclusions The prevalence of vitamin D deficiency is still high in healthy children,and it increases with age.Vitamin D deficiency is one of the risk factors for decreased serum ferritin.Therefore,it is necessary to extend the duration of vitamin D supplements to reduce the prevalence of vitamin D deficiency in children.Besides,vitamin D concentration is suggested to be tested to rule out vitamin D deficiency for children with iron deficiency or poor efficacy of iron supplements.