117例急性脑血管病血清NSE和IL-6变化的临床意义

The detecion of neuron specific enolase and interleukin-6 in serum of 117 patients with acute cerebrovascular diseases

目的 :研究急性脑血管病患者血清神经元特异性烯化酶 (NSE)和白细胞介素 6 (IL 6 )的变化及其临床意义。方法 :应用免疫放射分析 (IRMA)法测定血清NSE含量和应用放射免疫分析 (RIA)法测定血清IL 6含量。结果 :急性脑血管病患者发病 3日内血清NSE含量高于正常对照组 (P <0 .0 1)和两周时 (P <0 .0 1) ;血清IL 6含量高于正常对照组 (P <0 .0 1) ,两周时接近正常 (P >0 .0 5 ) ;二者呈正相关 (P <0 .0 1)。结论 :急性脑血管病患者早期血清NSE和IL

Objective: To study the changes of serum NSE and IL 6 in acute cerebrovascular diseases and their clinical significance.Methods:The serum level of NSE of by immunoradiometric assay (IRMA) and the serum level of IL 6 were determined by radioimmunoassay (RIA).Results:NSE serum levels of patients were significantly higher (P<0.01) and IL 6 serum level were signficantly higer (P<0.01) in 3 days than that in two weeks and that in the controls.There was affirmative correlation between serum NSE level and IL 6 serum level (P<0.01).Conclusion:There was a close relationship between the serum level of NSE,IL 6 and clinical features of patient in the early stage of acute cerebrovascular diseases.