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靶向β和γ分泌酶治疗阿尔茨海默病的研究进展 被引量:6

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摘要 β淀粉样蛋白沉积所形成的老年斑是阿尔茨海默病 (AD)的三大病理改变之一。淀粉样蛋白代谢关键的分泌酶成为治疗AD很有潜力的靶点 ,β和γ分泌酶及其抑制剂成为AD的研究热点。本文介绍了近年来在 β淀粉样蛋白假说、分泌酶及其抑制剂上所取得的研究进展和尚存在的不足 ,为此类新药的开发提供一个很好的参考依据。
作者 肖飞 罗焕敏
出处 《国外医学(药学分册)》 CAS 2002年第5期272-278,共7页 Foreign Medical Sciences(Section of Pharmarcy)
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同被引文献124

  • 1肖飞,罗焕敏,李晓光,章佩芬,翁文,高勤.广东海风藤提取物HS_2对老年痴呆小鼠的药效学研究[J].中国药理学通报,2004,20(9):1001-1003. 被引量:18
  • 2肖飞,罗焕敏,李晓光,章佩芬,高勤,翁文.五味子乙素对M146L细胞分泌β淀粉样蛋白的影响[J].中国新药杂志,2005,14(3):290-292. 被引量:17
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