相转移催化不对称碳烷化研究 光学活性的二氢吲哚酮类衍生物的合成

Asymmetric C-alkylation by Chiral Phase-tranfer Catalysis Synthesis of Optically Active Derivatives of 2-Indolinone

本文报道了手性季铵盐1-7催化溴代烷与1,3-二甲基-5-甲氧基-2-二氢吲哚酮(8)的不对称3-C烷化反应,并通过研究不同的催化剂结构、溶剂、温度及溴代烷结构对产物光学活性的影响,讨论了不对称诱导机理。

By using different chiral quaternary ammonium salts (1--7) as phase-transfer catalysts, the asymmetric C-alkylation of 1, 3-dimethyl-5-methoxy-2-indolinone (8) with various alkyl bromides is reported. The inflences of chemical structure of catalysts and alkylating agents, solvents, reaction temperatures on the optical activity of the products were studied and mechanism of asymmetric induction was discussed.