异常妊娠与弓形虫、巨细胞病毒感染关系及婴儿期发育随访

Relationship between abnormal pregnant outcome and toxoplasma gondii,cytomegalovirus infection and infant development

目的 探讨异常妊娠与孕期弓形虫 (TOX)、巨细胞病毒 (CMV)感染的关系 ,异常妊娠结局对活产儿婴儿期发育的影响。方法 发生异常妊娠的孕妇 5 0例作为病例组 ,正常妊娠的 10 0例为对照组 ,检测孕期血清中弓形虫、巨细胞病毒特异的IgM、IgG抗体。对异常妊娠的活产儿 36例 ,用Gesell发育诊断法评价其婴儿期的发育情况 ,以正常足月儿72例为对照。结果 病例组两种病原体的现时感染率均高于对照组 ,且差异有显著性 ;两组的过去感染率差异无显著性。异常妊娠儿的总发育商及精细动作、语言、个人 -社交及大动作能区发育商均低于对照组 ,差异有显著性。结论 为了提高人口素质 ,应加强孕期保健 ,对于异常妊娠的活产儿采取早期干预措施 。

Objective To explore the effect of toxoplasma gondii and cytomegalovirus infection on pregnant outcomes and the effect of abnormal pregnant outcome on infant development. Methods 50 women with abno rmal pregnant outcome were paired with 100 normal pregnancy women and tested for TOX IgM/IgG and CMV IgM/IgG with ELISA in their serum. 36 infants with abnormalities including low birth weight,premature, low Apgar score and IUGR, compared with 72 normally born infants,were evaluated using Gesell developmental scales. Results Present infection rate in the case group was significantly hig her than the control group. The infants of the abnormal outcome group had lower DQ.Conclusion The results showed that infections occurring in pregna ncy had adverse effect and we should reinforce surveillance before and during pregnancy. We should also take early intervention to promote the development of premature,low birth weight, IUGR and asphyxia child.