鼻咽癌患者血清血管内皮生长因子检测及临床意义

The study of vascular endothelial growth factor in nasopharyngeal carcinoma patients before and after radiotherapy

目的 :探讨鼻咽癌患者放疗前后血清中血管内皮生长因子 (VEGF)的变化及临床意义。方法 :应用酶联免疫吸附法 (ELISA)对 4 6例鼻咽癌患者放疗前后血清中VEGF水平进行检测。结果 :鼻咽癌患者放疗前血清VEGF水平明显高于正常人 (P <0 .0 1) ,并随病情进展而升高 ;放疗后VEGF水平较放疗前明显降低 (P <0 .0 1)。VEGF水平 >15 0ng/L与 <15 0ng/L者的复发或转移率有明显差异 (P <0 .0 1)。结论 :VEGF不仅与鼻咽癌发生、发展有关 ,而且与其预后也密切相关 。

Objective:The purpose of this study was to determine the serum vascular endothelial growth factor (VEGF) level before and after radiotherapy in the nasopharyngeal carcinoma. Method:In this study we used the methods of ELISA to test the serum VEGF level of 66 cases which including 46 cases of nasopharyngeal carcinoma and 20 cases of healthy controls.Result:The serum VEGF levels in nasopharyngeal carcinoma patients were significantly higher than those of healthy controls (P< 0.01 ).The serum levels of VEGF were significantly reduced at the end of radiotherapy (P< 0.01 ). The recurrence or metastasis rate was significantly higher in cases with >150 ng/L VEGF level than those with <150 ng/L. Conclusion:VEGF plays an important role in the growth and prognosis of nasopharyngeal carcinoma.