不同ABO血型肝病患者的免疫功能及其与预后的关系

Study on prevalence of immune function among hepatopaths with different ABO groups

目的探讨不同ABO血型的各型肝病患者体液和细胞免疫指标改变状况。方法应用免疫扩散和APAAP桥联酶标等方法,检测健康对照组(NC)500例、乙肝标志物阳性的各型肝炎562例,分别测定体液及细胞免疫功能。结果各肝病组与NC组相比,体液免疫指标改变明显,自ASC至PHC,IgE递增显著,IgD、IgG次之,PHC组C3、CIC明显升高,E-RFC明显降低。AB血型的肝病IgG、IgE、C3、CIC明显升高,E-RFC显著降低,AB血型的LC和PHC患者CD4+、CD4+/CD8+明显降低,与其他各血型组和NC组相比,差异有显著性意义(P<0.05)。在HBV感染者中,AB血型者易于发生LC和PHC,这一血型的肝病患者易出现体液免疫亢进和细胞免疫功能不足。

Objective To investigate the changes of humora l and cellular immunity markers in va rious liver disease by ABO blood group,the reliable evidences were provided.Methods The cases of 500health men(NC)as contrals,various acute and chronic liver disease with the positive index of hepatitis B which include acute hepatitis(ASC)140cases ,chronic hepatitis(CH)192cases,post -hepatitis cirrhosis(LC)160cases,primary hepatocellular c arcinoma (PHC)70cases were examined by im-mune-spresding assay,APAAP imunne-bridge assay and so on in the study ,t he changes of serumal IgG,IgM,IgA,I gD,IgE,complement C 3 (C 3 ),total complment (CH50),circulatory immune complex(CIC),E-rosetter formation rate(E-RFC)and T-lymphocyte subsets in the group of NC ,ASC,CH,LC and PHC were investigated respectively.Results Compared to con-trals,the humoral immune markers of all groups of liver disease changed m arkedly,IgE increased changed apparently and IgG increased .Secondly from ASC,CH,LC,to PHC,mean while,C 3 and CIC increased obviously and E-RFC decreased obviously in the group of PHC.Compared to the grou p of other blood type incresed marked ly(P<0.05),whose E-RFC decreased markedly(P<0.05),CD 4+ ,CD 4+ /CD 8+ of LC and PHC diseases with AB blood ty pe also decreasd markedly(P<0.05).Conclusion In the HBV-infected population the p atients with AB blood type suffered f rom LC and PHC easily and got hyper -hu moral immune function and hypo-cellular immune f unction easily.[