图像分析技术在甲状腺滤泡性肿瘤诊断中的应用

Videomorphometric Analysis of Tthyroid Follicular Tumor

目的 探讨图像分析技术在甲状腺滤泡性肿瘤良恶性鉴别诊断中的价值。方法 应用北航第三代CMM - 3病理图像分析系统 ,对 30例甲状腺滤泡性肿瘤 (2 0例腺瘤 ,10例腺癌 )及 10例正常甲状腺上皮组织进行形态定量测定 ,每例随机测量 5 0 - - 10 0个细胞核的面积、周长、平均核直径、形状因子 ,异形指数 5个参数。结果 上述 5个参数在正常与恶性、良性及恶性组间均有极显著性差异 (P <0 0 0 1)。结论 图像分析对甲状腺滤泡性肿瘤的病理鉴别诊断具有一定价值。

Objective To explore the significance and practical value of videomorphometric analysis in differential diagnosis of the thyroid gland in benign and malignant follicular lesions. Methods A videomorphometric analysis of surgically resected thyroid follicular tumors and normal thyroid gland was respectively performed with CMM-3 image analysis system. 50-100 tumor cell nuclei each case were studied at random for their area, perimeter, average diameter, shape factor and atypical index.Results Hightly significant statistical difference was observed in every parameter between normal and malignant, benign and malignant cases.Conclusion It is suggested that videomorphometry is an useful tool for the differential diagnosis of benign from malignant tumors of thyroid gland.