摘要
目的 :探讨头孢拉定与甲硝唑合并应用时 ,体内甲硝唑血浓度与药动学有否影响。方法 :家兔试验 ,分别给送服甲硝唑 2 0 0 mg,于给药后一定时间分别取血测定。间隔一周后 ,再分别送服甲硝唑 2 0 0 mg+头孢拉定 2 5 0 mg,同样时间取血分别测定血药浓度及药动学参数。结果 :头孢拉定与甲硝唑合用时 ,可使甲硝唑血药浓度升高 。
The concentration of metronidazole in blood was determined by spectrophotometry with rabbits having taken metronidazole or metronidazole combined with cephradine. The pharmaconkinetics parameters of two groups was computed and sorted by statistic method. The results showed that the concentration of metronidazle in blood could be increased by cephradine, but the change of pharmacokinetics parameters was not significance.
出处
《实用医技杂志》
2002年第11期846-847,共2页
Journal of Practical Medical Techniques
关键词
头孢拉定
甲硝唑
血药浓度
药物代谢动力学
cephradine
metronidazole
blood plasma concentration
pharmacokinetics parameters
