大白鼠扣带回3区向杏仁体及其他核群的纤维投射——菜豆白细胞凝集素顺行示踪研究

PROJECTIONS FROM CINGULATE CORTEX AREA 3 TO AMYGDALA AND OTHER NUCLEI IN THE RAT——A PHASEOLUS VULGARIS LEUCOAGGLUTININ (PHA-L) ANTEROGRADE TRACING STUDY

本文用菜豆自细胞凝集素免疫组织化学顺行示踪技术,观察大白鼠扣带回3区(Cg3)向皮质下核团的纤维投射。其投射区自前向后主要有:伏核、尾壳核内侧1/3、终纹床核、外侧视前区、带旁核、丘脑前内侧核、背内侧核、前室旁核、网状核、外侧缰核、后室旁核、束旁核及丘脑筛状核等。在丘脑下方,标记纤维密集于未定带、内囊的内侧边缘区和乳头丘脑束的周围。自这些区域,有纤维投射至下丘脑外侧区。本文着重分析了标记纤维在杏仁体的分布情况,标记纤维密集于基底外侧前核和外侧核的腹内侧亚核。从而证实Cg3皮质的纤维投射参与基底外侧核一边缘系环路,即所谓记忆环路。而杏仁体中央核仅偶见极稀疏的标记纤维。所以我们认为,Cg3皮质未参与“内脏环路”。标记纤维自注射侧经胼胝体膝至对侧半球,其投射区与注射侧的投射区一致,但标记纤维比较稀疏。

Projections from cingulate cortex area 3(Cg3) to the subcortical nuclei in the rat were examined by using phaseolus vulgaris leucoagglutinin (PHA-L) immunohistochemical anterograde tracing method. The projecting topography showed rostrocaudally as follows: accumbens, medial 1/3 part of caudate-putamen, bed nucleus of stria terminalis, lateral preoptic area, paratenial thalamic nucleus, anteromedial thalamic nucleus, mediodorsal thalamic nucleus, anterior paraventricular thalamic nucleus, reticular thalamic nucleus, lateral habenular nucleus, posterior paraventricular thalamic nucleus, parafascicular thalamic nucleus and ethmoid thalamic nucleus etc. Beneath the thalamus, labeled fibers were densely distributed in zona incerta, the medial edge of internal capsule and the area surrounding mammillothalamic tract. From the areas mentioned above, fibers also projected into lateral hypothalamic area. The present paper paid a special attention to the distribution of the labeled fibers of amygdala. In amygdala, labeled fibers were converged in the anterior nucleus of basolateral nucleus and the ventromedial nucleus of lateral nucleus and thus it was confirmed that the Cg3 cortex projections took part in the 'basolateral-limbic circuit', the so called 'memory circuit'. However, in the central nucleus of amygdala sparse labeled fibers could only be found occasionally. In view of this fact, we did not consider that the Cg3 cortex took part in the 'visceral circuit'. Labeled fibers from the injection side passed through the genu of corpus callosum to the contralateral hemisphere, and the projection topography was basically similar to but less dense than that of the injection side.