不同感染途径对艾滋病病人疾病进程的影响

Effect of Different Transmission Routes on Disease Progression in Patients with AIDS

目的 了解经不同途径感染艾滋病病毒(HIV)的艾滋病(AIDS)病人疾病进程的差异。方法 按感染途径不同,分析48例AIDS病人感染HIV至发生AIDS的时问及初诊时外周血CD4淋巴细胞计数的差异。结果 感染HIV至发生AIDS的时间依次为:通过静脉注射毒品(IVDU)感染(3.5±1.6年)<通过输血或血制品感染(6.0±0.5年)<通过性行为(7.5±0.6年)感染,其差异有显著的统计学意义(P均<0.05)。初诊时,通过IVDU感染HIV的病人,其外周血CD4淋巴细胞计数(272.6±153.7/mm3)明显高于通过输血或血制品(18.2±11.3/mm3)及通过性行为(31.2±16.7/mm3)感染HIV的AIDS病人(P<0.05),而后两组AIDS病人的CD4淋巴细胞计数的差异无显著的统计学意义(P>0.05)。结论通过IVDU感染HIV的AIDS病人比通过输血或血制品及通过性行为感染HIV的AIDS病人发病早。通过输血或血制品感染HIV的AIDS病人,其疾病进程比通过性行为感染者快。

Objective To study the difference in disease progression m AIDS patients with different transmission routes. Methods: The time from acquiring HIV infection to the occurrence of AIDS and blood CD4 lymphocyte counts were compared among 48 AIDS patients according to their transmission roules. Result: The time from acquiring HIV infection to the development of AIDS in patients who got HIV infection via intravenous drug use (IVDU), blood transfusion and sex was 3.5 ±1.6 years, 6.0±0.5 years and 7.5 ±0.6 years, respectively.The differences among them were statistically significant (all P <0.05) .The number of CD4 lymphocytes in patients infected via IVDU(272.6 ±153.7/mm3) was significantly greater than that in patients infected via blood transfusion (18.2 ±11.3mm3)or via sex(272.6±53.7/mm) when admitted, but there was no difference in CD4 counts between the patients via blood transmission and via sex transmission.Conclusions:Palients with HIV infection via IVDU develop AIDS earlier than patients infected via blood transfusion or via sex intercourse. The disease progression in patients infected via blood transfusion is faster than patients via sex transmission.