糖尿病家系患者与血清瘦素水平的相关分析

Study on the correlation between serum leptin level and diabetes mellitus pedigree

目的 :探讨中国河南汉族糖尿病 (DM )家系患者与瘦素 (leptin)水平的相关性。 方法 :在中国河南汉族人群中选择 12个DM家系 ,符合常染色体显性遗传规律 ,全部成员 197例 ,共收集到外周静脉血标本 5 1例 ;111例 2型DM患者 (家系中患DM者不超过 2例 ) ;10 2例健康献血者作对照。用放射免疫技术测定血清leptin、C肽 ;对糖化血红蛋白、谷氨酸脱羧酶抗体、葡萄糖耐量 (OGTT)、体重指数 (BMI)等指标进行检测。结果 :DM家系与正常人群的leptin比较无显著性差异(P >0 0 5 ) ;111例 2型DM中男性及女性患者分别与 10 2例正常人群男性及女性leptin水平比较均有显著性差异 (P <0 0 5 ) ;2型DM人群中leptin水平分别与餐后 2h血糖水平、BMI呈正相关。 结论 :leptin在中国河南汉族DM家系人群中可能不是主要致病原因 ,血清leptin增高可能是 2型DM的致病原因之一。

Objective To study the correlation between DM pedigree and leptin in Han nationality in Henan,China.Methods Subjects in this study were 51 pedigree members who had family diabetic history,111 type 2 diabetic patients and 102 healthy controls from the Han nationality of Henan,China.Serum leptin,Serum C-peptide were measured by radioimmunoassay.OGTT,plasma hemoglobin A 1C ,glutamic acid decarboxylase antibody and body mass index(BMI) were also measured.Results There was no significant difference for leptin leptin levels between 51 pedigree members and 102 healthy controls (P>0.05).The leptin levels of male and female in 111 type 2 diabetic patients were significantly higher than those of 102 healthy controls(P<0.05).And the leptin was closely correlated to BMI(P<0.01) and 2h OGTT(P<0.01) in 111 type 2 diabetic subjects.Conclusion It is suggested that leptin didn't play an important role in the development of DM for pedigree members who had diabetic family history and increased serum leptin might be one of the risk factors related to type 2 DM.