代偿期乙肝肝硬化通过恩替卡韦联合替比夫定治疗的疗效分析

Efficacy analysis of entecavir combined with telbivudine in treating Hepatitis B cirrhosis in compensatory stage

目的：探讨代偿期乙肝肝硬化通过恩替卡韦联合替比夫定治疗的疗效。方法：研究我院2014 年6 月—2015 年12月收治的80 例代偿期乙肝肝硬化患者，分为对照组和观察组各40 例，其中对照组运用常规治疗，观察组运用恩替卡韦联合替比夫定治疗，分析两组患者治疗效果差异。结果：在治疗4～48 周，观察组HBV-DNA 转阴率显著高于对照组，两组差异具有统计学意义，P＜0.05；在治疗后肝功能、Child-Pugh 评分和纤维化指标上，观察组改善幅度要高于对照组，两组差异具有统计学意义，P＜0.05；治疗前后A/G、HA、LN、PC-Ⅲ、Ⅳ-C 上，观察组改善幅度均高于对照组，两组差异具有统计学意义，P＜0.05；在治疗总有效率上，观察组为95.0%，对照组为82.5%，两组差异具有统计学意义，P＜0.05。结论：代偿期乙肝肝硬化通过恩替卡韦联合替比夫定治疗可以有效提升治疗疗效，改善各相关功能指标，适用于临床广泛推广。

Objective: To investigate the therapeutic effect of entecavir combined with telbivudine in treating Hepatitis B cirrhosis incompensatory stage. Methods: 80 patients with Hepatitis B cirrhosis in compensatory stage, admitted to our hospital from June 2014 toDecember 2015, were divided into the control group and the observation group, with 40 cases in each group, the control group receivedconventional treatment while the observation group received entecavir combined with telbivudine, the different effects of two groups ofpatients were analyzed. Results: During 4 to 48 weeks of treatment, HBV-DNA negative rate of the observation group was significantlybetter than that of the control group, the difference was statistically significant, P<0.05; the improvement of the liver function aftertreatment, Child-Pugh score and fibrosis markers of the observation group was significantly better than that of the control group, thedifference was statistically significant, P<0.05; the improvement of A/G, HA, LN, PC-Ⅲ and Ⅳ-C, both before and after treatment, ofthe observation group was significantly better than that of the control group, the difference was statistically significant, P<0.05; Theeffective rate of the observation group was 95.0% and that of the control group was 82.5%, the difference was statistically significant, P<0.05. Conclusion: Entecavir combined with telbivudine could improve the therapeutic effect effectively in treating Hepatitis B cirrhosis incompensatory stage and improve the related functional indexes; therefore, it was applicable in wide clinical promotion.