淮南地区孕早期妇女TORCH感染筛查结果分析

Analysis of TORCH infection in early pregnant women in Huainan area of Anhui Province

目的分析淮南地区孕早期妇女弓形虫、风疹病毒、巨细胞病毒和单纯疱疹病毒的检测结果,探讨其临床意义。方法采用酶联免疫吸附试验(ELISA)对淮南地区4 832例孕妇TORCH-IgM抗体和TORCH-IgG抗体进行检测分析。结果 HSV-IgM和HSV-IgG阳性率最高,差异有统计学意义(P<0.05);因CMV感染导致的不良妊娠发生率为48.84%(21/43),与其他病毒感染导致的不良妊娠相比有统计学意义(P<0.05);不良妊娠结局表现中,流产发生率为65.12%(28/43),与其他不良妊娠结局表现相比,差异有统计学意义。结论淮南地区孕早期妇女存在一定的TORCH阳性率,TORCH感染是不良妊娠结局的重要危险因素之一,因此在孕早期或孕前进行TORCH检测对指导本地区优生优育工作及提高新生儿人口素质具有重要指导意义。

Objective To analyze the screening results of infection with Toxoplasma gondii(TOX), rubella virus(RuV), cytomegalovirus(CMV) or herpes simplex virus(HSV)(TORCH) among women in early pregnancy in Huainan area, and to explore the clinical implications by TORCH test. Methods Enzyme linked immunosorbent assay (ELISA) was performed to detect TORCH-IgM and TORCH-IgG antibodies in 4 832 pregnant women living in Huainan area. Results Highest positive rate of HSV- IgM and IgG was found in the pregnant women received TORCH tests(P<0.05), and 48.84% (21/43) adverse pregnancy outcomes were associated with CMV. The difference was significant compared to adverse pregnancies caused by other virus(P<0.05). Abortion(65.12%, 28/43) appeared dominant in the incidence of adverse pregnancy, which was statistically different from other causative factors. Conclusion Positive TORCH was detected in some women in early pregnancy in Huainan area, and TORCH infection is one of the important risk factors for adverse pregnancy outcomes. Therefore, TORCH test in the early stage of pregnancy or before pregnancy may have implications to improve local population quality of newborns.