脂必泰对2型糖尿病患者血脂代谢紊乱的调节作用

Regulation effect of Zhibitai capsule on lipid metabolism disorder in patients with type 2 diabetes

目的 探讨脂必泰对2型糖尿病患者血脂代谢调节作用的影响。方法 入选合肥市第一人民医院中医科于2011年3月~2012年3月收治的90例2型糖尿病合并血脂代谢紊乱患者，随机分为对照组和观察组，每组各45例，对照组应用辛伐他汀治疗，观察组应用脂必泰进行治疗，治疗时间为6周。检测并比较两组患者总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）以及低密度脂蛋白（LDL-C）治疗前后的变化；观察症状改善情况和用药期间的不良反应等。结果 与治疗前比较，两组治疗后TC、LDL-C的表达均有所降低、HDL-C的表达有所升高，差异具有统计学意义（P＜0.05），治疗后两组间上述指标比较无显著性差异（P＞0.05），观察组TG变化较对照组明显降低[（0.57±0.18）mmol/L vs.（0.37±0.06）mmol/L]，组间差异具有统计学意义（P＜0.05），不良反应发生率明显低于对照组（0% vs. 11.1%，P＜0.05），观察组患者胸闷、腹胀、气短症状改善情况明显优于对照组，上述指标组间均有显著性差异（P＜0.05）。结论 脂必泰对改善2型糖尿病患者的血脂代谢紊乱安全有效，值得在临床推广使用。

Objective To investigate Regulation effect of Zhibitai capsule on lipid metabolism in patientswith type 2 diabetes. Methods 90 type 2 diabetes patients with lipid metabolism disorder from The First People'sHospital of Hefei in 2011.3-2012.3 were randomly divided into control group (45 cases) and study group (45 cases).The control group received simvastatin. The study group received Zhibitai capsule. All were treated for 6 weeks.Total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C)were compared before and after treatment. Clinical symptoms and adverse events were observed. Results TCand LDL-C were decreased and HDL-C was increased significantly in both study group and control group aftertreatment (P<0.05), but were not different between these two groups (P>0.05). TG of study group was much lowerthan control group after treatment [(0.57±0.18) mmol/L vs. (0.37±0.06) mmol/L, P<0.05]. Rate of adverse eventswas obvious lower than control group (0% vs. 11.1%, P<0.05). More patients of study group had improvementof symptoms than control group, including chest distress, abdominal distension and shortness of breath (P<0.05).Conclusion Zhibitai capsule is more effective and safe for lipid metabolism disorder in type 2 diabetes mellituspatients, and is worth popularizing in clinic.