肠外营养联合生长激素用于胃肠肿瘤的疗效及安全性评价

Clinical effect and safety of parenteral nutrition and growth hormone in the treatment of gastrointestinal tumor

目的探究生长激素与肠外营养联合用药治疗的意义,为改善胃肠肿瘤患者生活质量提供理论依据。方法选取90例因胃肠肿瘤入院治疗的患者,按入院时间分为单一组与联合组,每组45例。单一组术后对45例患者给予肠外营养支持,联合组在单一组治疗基础上加用生长激素,观察两组患者能量代谢情况,统计用药期间不良反应发生情况。结果治疗4 d以及8 d后联合组白蛋白指标恢复情况较单一组恢复情况好(P<0.05);单一组不良反应发生率高达17.8%,联合组仅为6.7%。结论肠外营养支持可有效提高患者术后恢复,若与生长激素联合用药,可获得更好疗效且不良反应少。

Objective To study the clinical effect of growth hormone and parenteral nutrition and provide the clinical theory basis on the improvement of life quality for patients with gastrointestinal cancer. Methods 90 patients with gastrointestinal tumor were selected. The subjects were divided into two groups according to the admission time of hospital, 45 cases each group. The single group adopted the parenteral nutrition; the combined group adopted the parenteral nutrition and growth hormone. The energy metabolism and adverse event rate for two groups were observed. Results After 4d and 8d of treatment, the index of albumin for combined group was better than that of single group( P < 0.05). The adverse event rate for single group( 17.8%) was higher than that of combined group( 6.7%). Conclusion The parenteral nutrition support can promote the patient’s fast recovery; the combined therapy of parenteral nutrition support and growth hormone can improve the curative effect and reduce the adverse reactions.