凝结芽孢杆菌活菌片联合加减逍遥散、硝呋太尔制霉菌素软胶囊治疗VVC

Clinical Study of Bacillus Coagulans Tablets Combined with Minus Xiaoyaosan Powder,Nifuratel nystatin Soft Capsule in Treatment of VVC

目的观察凝结芽孢杆菌活菌片联合加减逍遥散、硝呋太尔制霉菌素软胶囊对外阴阴道假丝酵母菌病（VVC）治疗和预防复发的效果．方法选取2013年6月至2014年12月在正定县妇幼保健院确诊为阴道假丝酵母菌病（VVC）的患者共108例，随机分为观察组54例，每天阴道放置硝呋太尔制霉菌素软胶囊1枚，共6d，口服加减逍遥散每日1剂，共7d，同时口服凝结芽孢杆菌活菌片3片，每天3次，首剂加倍，共14d；对照组54例，每天阴道放置硝呋太尔制霉菌素软胶囊1枚，共6d，同时口服安慰剂维生素C片1片，每天3次，共14d．分别于停药后3～7d、1个月、3个月、6个月随访，观察近期治疗效果和远期复发情况．结果停药后3d，观察组有效率为92.59%，对照组有效率为81.48%，2组比较差异有统计学意义（P＜0.05）；停药6个月，观察组复发率为9.26%，对照组复发率为20.37%，2组比较差异有统计学意义（P＜0.05）．结论阴道假丝酵母菌病在抗真菌治疗基础上，给予凝结芽孢杆菌活菌片调节肠道微生态环境，中药加减逍遥散利湿清热，疏肝理气，可提高近、远期疗效，明显降低复发率．

Objective To observe the effect of Bacillus coagulans tablets Combined with minus Xiaoyao powder, Nifuratel nystatin soft capsule in treatment of VVC. Methods A total of 108 cases of VVC. patients were randomly divided into 2 groups: observation group and control group. In the observation group (n = 54), patients were given vaginal placement of Nifuratel nystatin soft capsule, 1 capsule daily, for 6 days; oral administration of minus Xiaoyao powder,1 agent daily,for 7 days; and oral administration of Bacillus coagulans tablets, 3 tablets one time, 3 times a day,for 14 days, double dose at first. In control group (54 cases), patients were given vaginal placement of Nifuratel nystatin soft capsule, 1 capsule daily, for 6 days; and oral placement of vitamin C tablet, 1 tablet one time, 3 times a day,for 14 days. The short-term effect and the long-term recurrence of were observed 3-7 days, 1 months, 3 months, 6 months after stopping drug treatment. Results 3 days after stopping drugs, the effective rate in the observation group and the control group was 92.59% and 81.48%, respectively,the difference between the two groups was statistically significant( <0.05) . 6 months after stopping drugs, the recurrence rate was 9.26% in the observation group, and 20.37% in the control group, the difference was statistically significant ( <0.05) . Conclusion For Vaginal candidiasis, on the basis of antifungal therapy, giving Bacillus coagulans tablets for regulation of intestinal micro ecological environment, and traditional Chinese medicine minus Xiaoyao powder for clearing heat and removing dampness,soothing the liver,can significantly improve the short termand long termcurative effects,and reduce the recurrence rate.