盆腔炎患者血清C反应蛋白、白介素-2、单核细胞趋化蛋白-1及血液流变学的变化

The Changes of Serum CRP,IL-2,MCP-1 and Hemorheology of Patients with Pelvic Inflammatory Disease

目的探讨盆腔炎患者血清中C反应蛋白(C reactive protein,CRP)、白介素-2(Interleukin-2,IL-2)、单核细胞趋化蛋白-1(monocyte chemoattractant protein-1,MCP-1)以及血液流变学的变化.方法选取2013年5月至2015年5月计划生育服务站收治的80例盆腔炎患者为观察组,另选取同期进行健康体检的60例健康妇女为对照组,比较2组人员血清CRP、IL-2、MCP-1水平以及血液流变学指标,并对比不同严重程度患者各检测指标的变化.结果观察组患者血清中CRP、MCP-1以及血液流变学指标均显著高于对照组,差异具有统计学意义(P<0.05);且重度盆腔炎患者血清中CRP、MCP-1以及血液流变学指标高于中度和轻度患者,中度盆腔炎患者又高于轻度患者,差异均具有统计学意义(P<0.05).观察组患者血清中IL-2水平显著低于对照组,且重度盆腔炎患者低于中度和轻度患者,中度盆腔炎患者又低于轻度患者,差异均具有统计学意义(P<0.05).结论盆腔炎患者血清中CRP、IL-2、MCP-1以及血液流变学指标较健康妇女均有显著变化,且轻度、中度及重度盆腔炎患者各指标也存在明显差异.

Objective To investigate the changes of serum C reactive protein (CRP), Interleukin-2(IL-2), Monocyte chemoattractant protein-1 (MCP-1) and hemorheology in patients with pelvic inflammatory disease. Methods Eighty patients with pelvic inflammatory disease were enrolled as observation group from May 2013 to May 2015,60 healthy women in the same age were selected as control group at the same period. The serum CRP, IL-2, MCP-1 and hemorheology were compared between observation group and control group; the detection indexes were compared in patients with mild, moderate and severe pelvic inflammatory disease in observation group.Results The serum levels of CRP and MCP-1 and hemorheology of observation group were higher than those of control group, the differences were statistically significant( P<0.05) . The detection indexes of patients with severe pelvic inflammatory disease were higher than those of mild and moderate pelvic inflammatory disease, the detection indexes of patients with moderate pelvic inflammatory disease were higher than those of mild pelvic inflammatory disease, the differences were all statistically significant (P <0.05) . The level of IL-2 of was significantly lower than that of control group, the level of IL-2 of patients with severe pelvic inflammatory disease was lower than that of mild and moderate pelvic inflammatory disease, the level of IL-2 of patients with moderate pelvic inflammatory disease was significantly lower than that of mild pelvic inflammatory disease, the differences were all statistically significant ( P<0.05) . Conclusion The serum levels of CRP, IL-2, MCP-1 and hemorheology of patients with pelvic inflammatory disease have significant changes, and the detection indexes of patients with mild,moderate and severe pelvic inflammatory disease have significant differences.