猫爪草中的脂肪酸类化合物

Fatty Acids from Ranunculus ternatus

为了解小毛茛(Ranunculus ternatus Thunb.)的化学成分,采用色谱技术从其干燥块根猫爪草中分离纯化得到5个脂肪酸类化合物,经波谱分析,他们的结构分别鉴定为(R)-3-hydroxy-11-methoxy-11-oxoundecanoic acid(1)、十六烷酸(2)、棕榈酸乙酯(3)、已二酸(4)和硬脂酸(5)。其中,化合物1为新化合物,这些成分对耐药结核分枝杆菌(耐INH+RFP)有一定的体外抑制活性。

The aim is to investigate the chemical constituents of Ranunculus ternatus Thunb. Five fatty acids areisolated from tubers of R. ternatus. On the basis of spectral data, they are identified as (R)-3-hydroxy-11-methoxy-11-oxoundecanoic acid (1), palmitic acid (2), ethyl palmitate (3), adipic acid (4) and stearic acid (5).Compound 1 is a new compound. All compounds have a certain inhibitory activities in vitro against multidrugresistantstrain.