疏肝理脾祛风汤联合盐酸非索非那定片治疗慢性荨麻疹肝郁脾虚证的临床疗效

Clinical efficacy of Shugan Lipi Qufeng decoction combined with fexofenadine hydrochloride tablets in treating chronic urticaria liver qi stagnation and spleen deficiency syndrome

目的:观察疏肝理脾祛风汤合并盐酸非索非那定片治疗慢性荨麻疹肝郁脾虚证的临床疗效。方法:采用随机分组对照法将2015年4月—2015年12月在我院皮肤科就诊的慢性荨麻疹肝郁脾虚型患者60例分为观察组和对照组各30例。观察组给予疏肝理脾祛风汤联合盐酸非索非那定片治疗;对照组单纯给予口服盐酸非索非那定片治疗。2周为1个疗程,共2个疗程。观察临床疗效、全身症状及皮损症状的缓解情况。结果:1观察组总有效率为93.3%,明显优于对照组的76.7%。两组之间差异明显(P<0.05)有统计学意义。2两组在治疗后均能有效控制患者总体症状,都是有效治疗药物。并且观察组疗效优于对照组。两组治疗前后在瘙痒程度、发作频率、皮肤划痕症、皮损分布、持续时间、风团大小、风团数量等指标中,(P<0.05)均有显著性差异,观察组明显优于对照组,更能改善荨麻疹的局部症状及全身症状,提高患者生活质量。3停药1个月后随访发现观察组复发率(13.3%),对照组(30%),两组比较有显著差异(P<0.05)。结论:疏肝理脾祛风汤联合盐酸非索非那定片治疗慢性荨麻疹肝郁脾虚证,临床疗效好,能改善此证的全身症状及皮损症状,不良反应少,复发率低,安全可靠,值得临床推广。

Objective: To observe the clinical effect of Shugan Lipi Qufeng decoction combined with fexofenadine hydrochloridetablets in treating chronic urticaria liver qi stagnation and spleen deficiency syndrome. Methods: 60 patients with chronic urticaria liver qistagnation and spleen deficiency syndrome, who were treated in the dermatological department of our hospital from April 2015 toDecember 2015, were randomly divided into the observation group and the control group, with 30 cases in each group. The observationgroup received Shugan Lipi Qufeng decoction combined with fexofenadine hydrochloride tablets while the control group only receivedfexofenadine hydrochloride tablets. Two weeks formed one course and the treatment lasted two courses. The clinical effect and the relief of systemic symptoms and skin lesions were observed. Results: ①The total effective rate of the observation group was 93.3%, which wassignificantly higher than that of the control group, 76.7%, the difference between two groups was statistically significant (P < 0.05). ②After treatment, the general symptoms of the patient of two groups were controlled and the treatments were all effective, but the clinicaleffect of the observation group was better than that of the control group. There were significant differences in indexes such as degree ofitching, seizure frequency, skin scratch disease, skin lesions distribution, duration and the size and number of wheals before and aftertreatment (P < 0.05), the observation group was better than the control group in improving the local symptoms and systemic symptoms andenhancing the quality of life of urticaria patients. ③Follow up 1 month after stopping taking drug showed that the recurrence rate of theobservation group and the control group was 13.3% and 30% respectively, the difference between two groups was statistically significant(P < 0.05). Conclusion: Shugan Lipi Qufeng decoction combined with fexofenadine hydrochloride tablets had good clinical effect intreating chronic urticaria liver qi stagnation and spleen deficiency syndrome; it could relieve the systemic symptoms and skin lesions andwas of less adverse reaction and low recurrence rate, which was safe and reliable, therefore, it was worthy of clinical promotion.