白介素类因子及肿瘤坏死因子-α在小儿肺炎支原体肺炎中的检测意义

Detection value of interleukin-class factor and tumor necrosis factor-α for infantile Mycoplasma pneumoniae

目的:探讨白介素类因子及肿瘤坏死因子-α在小儿肺炎支原体肺炎中的检测意义。方法:选择我院收治的肺炎支原体肺炎患儿60例,作为观察组,同时选择在我院体检健康儿童50例作为对照组。测得上述对象白介素-6、白介素-8、白介素-10及肿瘤坏死因子-α水平。结果:观察组治疗前的白介素-6、白介素-8、白介素-10及肿瘤坏死因子-α水平高于对照组,差异有统计学意义(P<0.05)。观察组治疗后的白介素-6、白介素-8、白介素-10及肿瘤坏死因子-α水平和对照组比较,差异无统计学意义(P>0.05)。合并有肺纤维化样改变患儿胸腔积液白介素-8、肿瘤坏死因子-α水平高于本组血清胸腔积液白介素-8、肿瘤坏死因子-α水平,差异有统计学意义(P<0.05);合并有肺纤维化样改变患儿胸腔积液白介素-8、肿瘤坏死因子-α水平高于无纤维化样改变患儿,差异有统计学意义(P<0.05)。结论:白介素-6、白介素-8、白介素-10及肿瘤坏死因子-α在儿童肺炎支原体肺炎发病早期其水平升高,检测其水平有助于临床诊断,有助于了解此类患儿预后。

Objective: To investigate interleukin-class factor and tumor necrosis factor-α for the detection of children withMycoplasma pneumoniae pneumonia. Methods: 60 casesadmitted to our hospital with Mycoplasma pneumoniae pneumonia were taken asobservation group, while 50 cases of healthy children were taken as a control group. The interleukin-6, interleukin-8, interleukin-10 andtumor necrosis factor-α levels were measured in both groups. Results: The pre-treatment value of interleukin-6, interleukin-8,interleukin-10 and tumor necrosis factor-α levels werehigher, andthe difference was statistically significant (P<0.05). The values ofinterleukin-6, interleukin-8, interleukin-10 and tumor necrosis factor-α levels in the observation group after treatment and the controlgroupshowed statisticallyinsignificant differences (P>0.05). Associated with pleural effusion in children with pulmonary fibrosis-likechanges in interleukin-8, tumor necrosis factor -α higher than the present level of serum pleural fluid interleukin-8, tumor necrosis factor-αlevels, the difference was statistically significant (P<0.05); associated with pulmonary fibrosis-like changes in children with pleural fluidinterleukin-8, tumor necrosis factor-α higher than children with no fibrosis-like changes, the difference was statistically significant (P<0.05). Conclusion: interleukin-6, interleukin-8, interleukin-10 and tumor necrosis factor-α raising its level in the early onset of childhooddetects the pneumonia mycoplasma pneumonia, detected levels contribute to clinical diagnosis, prognosis is helpful to understand thesechildren.