依那普利与丹参酮对肺心病急性加重期患者血液流变学及心功能的改善作用分析

The effect of enalapril and tanshinon on hemorheological and cardiac function of patients with acute exacerbation of chronic pulmonary heart disease

目的:探讨依那普利与丹参酮联合治疗肺心病急性加重期(AECPHD)的疗效及对患者血液流变学、心功能的影响。方法:84例AECPHD患者随机分为观察组与对照组,各42例。对照组予以依那普利口服,观察组在对照组的基础上予以丹参酮治疗,对比两组的疗效、血液流变学指标及心功能指标变化。结果:观察组的总有效率为95.2%,显著高于对照组的81.0%(P<0.05);治疗后观察组的LVEF、CO及SV均显著高于对照组,m PVP、WBHSV、WBLSV、PV、HCT及Fg显著低于对照组(P<0.05)。结论:依那普利与丹参酮联合治疗AECPHD能够有效改善患者的血液流变学状态及心功能,提高临床疗效,且药物不良反应能够耐受。

Objective: To investigate the efficacy and effect of enalapril and tanshinon on hemorheological and cardiac function ofpatients with acute exacerbation of chronic pulmonary heart disease (AECPHD). Methods: 84 cases of AECPHD patients were randomLydivided into the observation group and the control group, with 42 cases in each group. The control group received oral administration ofenalapril while the observation group received tanshinon treatment on the basis of the treatment of the control group. The efficacy, changesof the hemorheology and heart function indexes of the two groups was compared. Results: The total effective rate of the observation groupwas 95.2%, which was significantly higher than that of the control group (P<0.05); After treatment, the LVEF, CO and SV of theobservation group were significantly higher than that of the control group, mPVP, WBHSV, WBLSV, PV, HCT and Fg of the observationgroup were significantly lower than that of the control group (P<0.05). Conclusions: The combined treatment of enalapril and tanshinoncould improve the hemorheology status and cardiac function of AECHPD patients, it could promote the clinical efficacy, and the adversereactions could be tolerated.