加味补阳还五汤与依达拉奉对急性脑梗死患者血浆溶血磷脂酸水平的影响

Effects of the Buyang Huanwu decoction and Edaravone on plasma LPA level of acute cerebral infarction

目的:观察加味补阳还五汤与依达拉奉对急性脑梗死患者血浆溶血磷脂酸(LPA)水平的影响。方法:将80例急性脑梗死患者随机分为观察组(40例)和治疗组(40例),两组均给予依达拉奉治疗;治疗组加用补阳还五汤,治疗1个疗程。检测两组患者治疗前后3、5、7和14d的血浆LPA浓度,并与健康体检者(正常对照组)比较。结果:两组治疗前血浆PLA水平显著高于正常对照组(均P<0.001);治疗后血浆PLA水平显著降低,治疗组治疗后14d与正常对照组相比差异无显著性(均P>0.05);治疗组治疗后5、7、14d血浆LPA水平显著低于观察组(均P<0.001),恢复正常亦较早。结论:加味补阳还五汤与依达拉奉能显著降低急性脑梗死患者的血浆LPA水平,抑制血小板聚集。

Objective: To observe efficacy of the Buyang Huanwu decoction and Edaravone on plasma LPA level of acute cerebral infarction. Methods: 80 patients were randomly divided into the obsered group (40 cases) and the treatment group (40 cases). Two groups were given Edaravone; the treatment group was treated with the Buyang Huanwu decoction more, for a course. Before treatment and in 3,7 and 14 days, the plasma LPA levels were measured, and compared with healthy subjects (the normal control group). Results: Before treatment, the plasma PLA levels in two groups were significantly higher than those in the normal control group (P<0.001). The different of plasma PLA levels in the treatment group (in 14 days) and the normal control group were not significant (P>0.05). The plasma PLA levels in the treatment group in 5, 7, 14 days were significantly lower than those in the observed group (P<0.001), with shorter time. Conclusion: The Buyang Huanwu decoction and Edaravone can significantly reduce the plasma LPA levels of patients with acute cerebral infarction,and inhibit platelet aggregation.