丁苯酞氯化钠注射液与依达拉奉联合在急性脑梗死中的应用

Application of Butylphthalide and Sodium Chloride Injection Combined with Edaravone in Acute Cerebral Infarction

目的:探讨丁苯酞氯化钠注射液与依达拉奉联合使用在急性脑梗死(ACI)患者中的应用效果。方法:150例ACI患者随机分成3组,每组50例。A组给予丁苯酞氯化钠注射液治疗,B组给予依达拉奉治疗,C组给予丁苯酞氯化钠注射液联合依达拉奉治疗,比较治疗前后3组患者的NIHSS评分、Barthel指数变化情况以及临床疗效。结果:治疗后3组患者的NIHSS评分均较治疗前有明显下降,Barthel指数有明显提高,其中以C组两项指标改善最为显著(P<0.01);C组患者的总有效率显著高于A组和B组(P<0.05)。结论:丁苯酞氯化钠注射液与依达拉奉联合用于ACI对神经功能缺损有良好改善效果。

Objective: To investigate the butylphthalide and sodium chloride injection and edaravone combined applicationeffect in patients with acute cerebral infarction (ACI). Methods: 150 patients with ACI were randomly divided into 3 groups, 50cases in each group. Given butylphthalide and sodium chloride injection in the treatment of group A, group B received edaravonetreatment, group C given butylphthalide and sodium chloride injection combined with edaravone treatment and comparedbefore and after treatment of 3 groups of patients NIHSS score, Barthel index changes and clinical curative effect. Results:After treatment with NIHSS scores of three groups of patients were compared with the treatment was decreased, the Barthelindex has increased significantly, which in C group two indicators improved significantly (P<0.01); patients in group C hada total efficiency was significantly higher than that in group A and group B (P<0.05). Conclusion: Edaravone combined withButylphthalide and Sodium Chloride Injection for ACI has good improving effect on nerve function defect.