康柏西普辅助玻璃体切除术治疗糖尿病视网膜病变

Effects of Conbercept Assisted Resection of Vitreous Body in the Treatment of Diabetic Retinopathy

目的:观察23G玻璃体切除术(PPV)辅助或不辅助康柏西普玻璃体注射(IVC)治疗,对增殖性糖尿病视网膜病变(PDR)患者手术操作及术后预后的影响。方法:55例(57只眼)PDR随机分为康柏西普辅助组(28眼,A组)和单纯玻切手术组(29眼,B组)。A组PPV术前注射康柏西普0.5mg;B组不使用康柏西普行PPV,比较两组在手术所需时间、术中医源性裂孔发生、术中出血、电凝及术后玻璃体积血发生率方面的差异和术后1月黄斑厚度及手术对视力改变方面的差异。结果:对两组病人的手术前平均年龄、最佳矫正视力、黄斑厚度进行比较,两组无差异。A组手术所需时间、出血及使用电凝、术后玻璃体积血发生率明少于B组,P<0.05;A组术中发生医源性视网膜裂孔与B组相当,P>0.05;术后1月,A组黄斑厚度明显薄于B组,P<0.05,A组术前术后视力提高明显高于B组。结论:对PDR术前玻璃体腔注射康柏西普可显著缩短手术时间,减少术中电凝使用及术中术后出血的发生,可提高患者视力,改善黄斑水肿。

Objective: To observe the 23G vitreous resection surgery assisted (PPV) or does not assist the conbercept intravitrealinjection (IVC) treatment of proliferative diabetic retinopathy (PDR) in patients with operation and postoperative prognostic impact.Methods: 55 cases (57 eyes) with PDR were randomly divided into conbercept assisted group (28 eyes, group A) and vitrectomy group (29eyes, group B). Group a PPV preoperative injection of Conbercept 0.5 mg; group B without using Compaq etanercept, PPV, were comparedbetween the two groups in operation required time, intraoperative iatrogenic fracture after the occurrence of hole, bleeding, electriccoagulation and postoperative vitreous hemorrhage occurred rate of differences and surgery January macular thickness and surgery on visualacuity change change differences. Results: The average age of the two groups of patients, the best corrected visual acuity, macular thicknesswere compared, there were no differences between the two groups. Operation in group A. the required time, bleeding and coagulation,postoperative vitreous hemorrhage occurred rate was obviously less than group B (P<0.05). In group A, the incidence of iatrogenicretinal breaks was comparable to that of B group, P>0.05. One month after operation, a group of macular thickness was significantlythinner in group B, P<0.05, a group of preoperative postoperative visual acuity improved was significantly higher than that in group B.Conclusions:The PDR preoperative intravitreal injection of conbercept can significantly shorten the time of operation, reduce the incidenceof intraoperative electric coagulation and operation in postoperative bleeding, can improve visual acuity, improve the macular edema.