姜黄素的结构修饰与抗肿瘤研究进展

Study Advances of Structural Modification and Antitumor Activities of Curcumin

姜黄素是一种天然的多酚类物质,广泛分布在多种植物中,并具有多种生物活性。但是其存在自身抗肿瘤作用较弱、生物利用度低等缺点,使其临床应用受到了限制。基于此,研究人员对姜黄素进行了大量的结构修饰,以期改善其抗肿瘤活性和成药性。本研究主要对姜黄素的结构修饰及抗肿瘤作用研究进展进行综述,旨在为以后合成高效专一活性的姜黄素衍生物提供依据。

Curcumin was a kind of natural polyphenol widely found in natural plants and had various biological activities. However,anti-tumor effect was weak and bioavailability of curcumin was poor, which had limited the potential clinical application. Based on this fact, researchers had conducted a great deal of structural modifications on curcumin, in order to improve its anti-cancer activities and druggability. In this paper, the research advances of the structural modification of curcumin, as well as anti-cancer activities were reviewed, and those would provide assistances for the subsequent synthesis of curcumin derivatives with high and specific biological activity.